The fundamental reform of the most popular fully c

Fully enclosed flexible packaging infusion: fundamental change in infusion containers

in the 1970s, a foreign student in China caught a cold. During the treatment process, bacteremia was caused by infusion pollution, and the Indian youth lost his life in vain. He is the son of the famous internationalist soldier Dr. Ko Tihua

in China, tens of thousands of patients treat diseases through infusion every day, ouyangming said. In the concept of ordinary people, infusion can not only directly deliver drugs and nutrition to critically ill patients, but also be more effective than oral drugs. In order to cure the disease as soon as possible, suffer less pain and do not delay work, many people take the initiative to ask doctors to adopt infusion therapy for them. As everyone knows, infusion also has great danger. If the liquid directly enters the patient's vein, there may be problems in the operation of medical staff, the quality of the liquid, the container containing the liquid and so on. Once the infusion reaction occurs, it is often a small thing. The light one has pyrogen reaction, and the serious one has unimaginable consequences

therefore, the quality of infusion is directly related to the effect of clinical treatment and the life safety of patients

infusion reaction is caused by pollution and particles. The pollution of infusion can be divided into endogenous and exogenous. Endogenous pollution usually occurs in the production process. In China, most of the infusion liquids are carried by glass bottles. Due to the characteristics of glass bottles, and the poor conditions and backward technology of some production units, reusing glass bottles or incomplete cleaning and disinfection, the liquids are contaminated by bacteria

for a long time, the clinical infusion treatment in China mostly adopts the semi open infusion system with glass bottles or hard plastic bottles as containers. During infusion, it is necessary to insert another vent pipe at the rubber plug at the bottle mouth to make air enter the bottle, pressurize the liquid and input it into the human body. Because the air inlet pipe is connected with the outside world, airborne pollutants are constantly in contact with the liquid. Dust and microorganisms in the air may enter the bottle through the air inlet pipe to pollute the liquid, and then enter the human body. This is the so-called exogenous pollution

relevant studies have shown that the probability of contamination of bottled infusion in hospital wards is 10 times that of infusion in clean rooms. During the preparation, sterilization, packaging and transportation of glass bottles, due to the characteristics of materials, there may be cracks and damages that are not easy to be detected by the naked eye, resulting in fungal infection and bacteremia, which endangers the life safety of patients

in addition, the rubber plug of the infusion bottle is prone to chemical pollution or particle shedding during high temperature and high pressure sterilization or use. The harm of particles to human body cannot be ignored. During infusion, particles produced by falling off of gas, rubber stopper and inner wall of glass bottle can enter the human body with the liquid. Once the elongation, stress, strain, damage value, average value, etc. are deposited in human brain, lungs, eyes and other organs, microthrombosis will be formed in capillaries or small arteries, blocking the human microvascular system, causing tissue damage in corresponding parts. It leads to pulmonary and cerebral embolism, granuloma, fundus arteriolar thrombosis and optic granuloma. Particles can also cause thrombolytic bleeding

in order to avoid the adverse reactions of infusion, developed countries began to use fully closed flexible packaging infusion as early as 30 years ago. The fully closed infusion system avoids the direct contact between the liquid and the outside air, eliminates the risk of embolism caused by bacteria, air pollution and bubbles, and makes patients safer

at present, China also has a Sino US joint venture Tianjin Baite medical supplies Co., Ltd., which can produce fully enclosed flexible packaging infusion systems. The bieffe clear flex flexible packaging infusion bag produced by the company adopts a triple composite film that is particularly suitable for storing liquids: the inner layer is inert polyethylene, non-toxic, which is an ideal material for direct contact with liquid medicine; The middle layer is polyamide, with low gas permeability and high mechanical strength; The main feature of outer polypropylene is low water vapor permeability. Bieffe flexible packaging infusion bag has the following characteristics: fully closed infusion system, eliminating the risk of infection; Completely transparent, easy to check before use; Good heat resistance, can be disinfected at 121 ℃; The air permeability and water permeability are very low, which can be preserved for a long time; The absorption rate of the drug is low and the drug solution is stable; Small size, light weight, in the same volume, its weight is only 60% of the glass bottle; High strength, convenient for transportation and storage; Unique valve design, no contact between solution and rubber plug; Environmental protection products, which can be deeply buried, naturally degraded or completely burned during post-treatment, do not pollute the environment. They are relatively ideal and advanced infusion packaging materials in the world at present. There are many electronic change experimental machine materials. A modern white factory stands in Tianjin Jinbei high tech park. Tianjin Baite medical supplies Co., Ltd. has passed the China GMP certification in December 1997 and ISO9001 certification in August this year

the forming, filling and sealing of bieffe infusion bags are completed at one time under the control of a computer in a 100 grade ultra clean environment. There are only 6 operators on the production line. The floor of the production workshop is cast by epoxy resin. The whole production environment is designed with an arc angle. The whole production process adopts seamless stainless steel pipes. Our plastic matrix is renewable biopolymer. The liquid is transported through rusty steel pipes. It is circulated continuously for 24 hours. The liquid making water is distilled from 160 meters of deep water underground. After double-layer packaging, it is disinfected at 121 ℃ high temperature, Ensure the safety of the product

biefei flexible packaging infusion bag not only provides a safer treatment method for patients, but also introduces the new concept of closed infusion to the Chinese medical community. We have reason to believe that the time has come for Chinese people to use the same safe infusion system as developed countries

source: Health News